Here’s your chance to bid on the opportunity to sit down for dinner with Felicity Huffman and William H. Macy.The dinner opportunity is going under the hammer to benefit Wilderness Workshop.Huffman recently joined the board of Wilderness Workshop, the conservation watchdog of nearly 4 million acres of public lands in western Colorado.“It is a profound honor to become a member of the Wilderness Workshop board,” Felicity said. “I remember Connie Harvey and Dottie Fox, founding members of the Wilderness Workshop, having breakfast with my mother, Grace, at the Weinerstube Restaurant in Aspen every Wednesday. I remember sitting next to my mother, eating her leftover pancakes, listening to Connie and Dottie talk about their efforts to save the wilderness in that wonderful piece of the world. I hope I can be worthy of continuing their work.”To make a bid on this auction, click here.
Companies in this story: (TSX:TRST)The Canadian Press TORONTO — CannTrust Holdings Inc.’s Danish partner says it has quarantined more medical pot products linked to illegal cultivation at the Canadian cannabis company’s greenhouse, and warned of possible shortages in Denmark as a result.Stenocare says it has received documentation that shows that five batches of the Danish company’s inventory originated in growing rooms that did not have government approval. The products have been isolated and blocked from being sold until the authorities have completed their investigation.The company added that “most, yet not all” of the CannTrust products in its inventory and that it has supplied to the Danish market since June 10 are linked to the unlicensed cannabis cultivation.This is a reversal of Stenocare’s comments earlier this week when it said only one “very small” batch was connected to the unlicensed growing, which Health Canada continues to investigate.CannTrust said Monday it had been notified by Health Canada that the regulator had discovered unlicensed cultivation at its Ontario greenhouse between October 2018 and March 2019, before the five rooms received the appropriate licences in April 2019.It said as a result, Health Canada put on hold roughly 5,200 kilograms of CannTrust products from that facility, and the licensed producer put a voluntary hold on an additional 7,500 kilograms of pot products which were also linked.“As a result of the new information, all products delivered from Stenocare relating to the batches in question will be put in quarantine… The most likely consequences from this new situation is that there will be a temporary shortage of medical cannabis products to the Danish market,” Stenocare said in a statement. “This will have negative financial consequences.”CannTrust announced a joint venture with Stenocare, that saw it receive a 25 per cent equity stake in the Danish company, in March 2018, and made its first shipment of cannabis oil to Denmark in September 2018.
LONDON — The British government says a major United Nations climate conference will be held in Glasgow next year if the U.K.’s bid to host the event is successful.The 26th Conference of the Parties to the United Nations Framework Convention on Climate Change is due to be held in late 2020 in either the U.K. — with a preliminary meeting in Italy — or Turkey.A decision is expected later this year.The British government said Friday that the two-week event would be held at the Scottish Events Campus beside the River Clyde. It’s expected to attract 30,000 delegates, including scores of world leaders.The meeting will assess progress five years after a 2015 Paris conference where nations reached a landmark agreement on reducing carbon emissions and limiting global temperature increases.The Associated Press
“Let his example and that of all our fallen colleagues continue to inspire us to believe – push us to act – and remind us that the power to transform our world is in our hands if we have the courage to use it,” Mr. Ban said in his remarks, which noted a wide range of challenges in which the resultant humanitarian misery must be addressed, from the crisis destroying Syria to what he called a “pandemic” of sexual violence around the world.The 2003 Canal Hotel bombing wounded more than 150 people and claimed the lives of 22 UN staff members, including Mr. Vieira de Mello, who was then the UN’s chief envoy to Iraq but was also well known for the various posts he had held with the Organization around the world. “As Sergio and our fallen colleagues proved in their too-short lifetimes, and as UN staff and our partners show today on the front-lines of war and disaster, the UN is dedicated to fulfilling its humanitarian imperative,” Mr. Ban said. “You can turn despair around. Never give up,” he urged, citing what he said was the lasting message of Mr. Vieira de Mello.In relation to Syria, where he noted that the UN and its humanitarian partners are doing all they can to provide assistance, Mr. Ban said, however, that “those with the political power to change things must answer to every mother and every girl and explain why they are not losing sleep over the relentless killing.” He stressed that the effort to pursue a military solution in Syria is leading to the dissolution of the Middle East country.Action was also needed to end the humanitarian misery in Mali, the Democratic Republic of the Congo (DRC) and Gaza, he said, calling them “headline crises,” that were the subject of steady media attention, which had not brought about decisive solutions.Less attention had been devoted to what he called forgotten crises, including the hostilities in the Central African Republic (CAR), where hundreds of thousands were in need and children were forced into fighting. In response to the UN appeal to donors for $129 million to relieve suffering in the CAR, he said, “to date, not one penny has been received. Not one penny.”Still less attention was devoted to what he called silent crises, such as sexual violence and the death of nearly one and a half million children suffering from easily preventable diseases, in addition to the thousands who die every day from hunger.“Where is the outrage?” he asked. “Whether headline crisis… forgotten crisis… or silent crisis… there should be no more indifference; no more neglect of early warning signs; no more excuses that problems are too big, too costly, too difficult,” he said.He said that the example of Timor-Leste, where Mr. Vieira de Mello served as transitional administrator and which successfully emerged from an independence struggle and several security crises in its short history, showed that the most difficult crises can end.Mr. Vieira de Mello did not shy away from those tough challenges and his example must be followed, Mr. Ban said. “Our shared challenge is to translate our humanitarian imperative into action.”
IRELAND CAPTAIN PAUL O’Connell says his side have the ability to beat the All Blacks on Sunday.The Munster lock has encountered defeat against New Zealand too many times before to be getting ahead of himself, but he says there is always a chance of upsetting the odds. The fact that Jonny Sexton, Brian O’Driscoll and Rob Kearney are all fit to start means Ireland have a team full of experience and talent.O’Connell believes that if every one of the Irish players plays to their full potential, the quality is there to beat the world’s best team. I think when you look at the talent we have in our team, we certainly can. That’s the question we’ve been asking ourselves all week and trying to put ourselves in the position to do that. There were defensive things from Samoa and Australia which needed to be addressed.“They were addressed early on in the week. We didn’t start as accurately as we would have liked and when you’re playing against these Southern Hemisphere teams, you need to get all the little things right.“We need to do that this weekend, and if we do that and players produce their best form, certainly we can win.”Ireland head coach Joe Schmidt backed up his captain’s sentiments at this afternoon’s team announcement, admitting that the All Blacks are an exceptional team but pointing out that Ireland will always have a chance.“I do believe that in any two-horse race there are no certainties. I think it would take an incredible performance, because the All Blacks are proving very resilient, as well as a class side. When they’ve come under pressure, they’ve overcome that pressure.“I think it was highly evident in the last couple of weeks, but also in South Africa in round six of the Rugby Championship. When you’re down to 14 men and down by six points, that you can score two converted tries and win by eight.“That’s pretty exceptional. It’s a clear sign of the resilience and self-belief they have. We have to have self-belief because I don’t think you can win if you don’t have self-belief.”Like rugby? Follow TheScore.ie’s dedicated Twitter account @rugby_ie >Sexton, O’Driscoll and Kearney named in Ireland team to face New ZealandEoin Reddan drops from Ireland duty onto Leinster bench
Some flight delays @DublinAirport due to strong gusty winds around the airfield, please check with your airline for latest flight info.— Dublin Airport (@DublinAirport) February 26, 2017 Source: RTÉ News/Twitter Share920 Tweet Email4 Source: An Garda Síochána/Twitter Storm Ewan causes flight delays at Dublin Airport Weather warnings are in place in 18 counties until 3pm today. By Gráinne Ní Aodha Sunday 26 Feb 2017, 2:30 PM Scenes from Kilkee, Co Clare where Storm Ewan has caused flooding pic.twitter.com/2YEYDLl783— RTÉ News (@rtenews) February 26, 2017 Updated, 2.30pmSOME FLIGHTS FROM Dublin Airport are delayed this afternoon due to Storm Ewan, as a weather warning came into effect in most southeastern counties.Dublin Airport advise to check your flight details to see if your flight has been affected Source: Dublin Airport/Twitter http://jrnl.ie/3259770 #StormEwan – Reports of flash flooding between Tuam and Ballinasloe. All motorists please drive with care. https://t.co/GYCHPRllkB pic.twitter.com/7Xr3uNUh62— An Garda Síochána (@GardaTraffic) February 26, 2017 69,216 Views Feb 26th 2017, 2:30 PM 34 Comments Met Éireann says it’ll be extremely windy until 3pm today, especially along southern coasts.The storm – although not as strong as Storm Doris last week – has caused some disruption.There are reports of flooding in areas including Tuam, Ballinasloe, and Kilkee Co Clare. There’s a Status Orange weather warning for counties Wexford, Cork, Kerry and Waterford as Storm Ewan brings strong winds speeds of 110 – 120km/h along southern and southeastern coastal counties.There’s a Status Yellow weather warning in place for Dublin, Carlow, Kildare, Kilkenny, Laois, Longford, Louth, Wicklow, Offaly, Westmeath, Meath, Clare, Limerick and Tipperary with wind speeds of 90 – 110km/h.Both warnings are in effect until 3pm today. Source: Met ÉireannWhen will it clear up?The rain is due to clear slightly by this afternoon, where it will get a bit brighter but stay cold, with highest temperatures of 7 to 11 degrees Celsius.It’ll be more windy than normal this evening, with showers and some hail expected, and with the risk of thunder.Earlier this week, Storm Doris cut power to over 50,000 homes across Ireland, caused traffic delays and flooding in certain areas.Read: ’They don’t want it slipping through their fingers’: Just what is happening with the Cork Event Centre?Read: ‘This is our weapon’ – Is the future of the protest in Ireland under threat? Short URL Tweet thisShare on FacebookEmail this article
L’écologie des sons : une nouvelle discipline scientifique ?Dans le magazine BioScience, un chercheur américain explique les enjeux de “l’écologie des sons”, une discipline qu’il a créée pour exploiter scientifiquement les informations fournies par les sons naturels, et pour faire renouer les gens avec ce patrimoine oublié.”Nous sommes habitués aux sons urbains, qui ne sont, la plupart du temps, que du bruit. Nous sommes tellement habitués à ‘bloquer’ [mentalement] ces bruits que nous ‘bloquons’ aussi les sons naturels. Si nous sommes déconnectés des sons de la nature, allons-nous continuer à la respecter et à l’entretenir ?”, demande Bryan Pijanowski, professeur à la Purdue University (Indiana). À lire aussiPourquoi le son de notre voix nous paraît-il si étrange sur un enregistrement ?Pour susciter un regain d’intérêt et d’attention sur ce domaine chez les citadins que nous sommes, mais aussi pour contribuer à l’essor des sciences environnementales, il a créé ce qu’il appelle “l’écologie des sons” ou “l’écologie des paysages sonores”, une discipline utilisant les compétences et les moyens techniques les plus divers pour analyser et interpréter les signaux sonores émis par la nature.La “biophonie” – sons issus des organismes vivants, par exemple l’intensité du gazouillis des oiseaux – et la “géophonie” – vent, tonnerre, phénomènes géologiques sonores…- sont, selon l’auteur, des indicateurs critiques précoces de tout changement au sein d’un écosystème : une source de données jusqu’à présent sous-estimée.Le 5 mars 2011 à 15:27 • Emmanuel Perrin
Australie : la plus grande mine à ciel ouvert du monde crée la colèreDes représentants écologistes et aborigènes australiens ont protesté contre l’autorisation qui a été donnée hier par le gouvernement pour la plus grande mine à ciel ouvert du monde. Selon les militants, cette mine pourrait provoquer une catastrophe sanitaire et écologique.Le gouvernement australien a donné l’autorisation au groupe anglo-australien BHP-Billiton (le plus grand groupe minier au monde) d’étendre son site d’exploitation de cuivre, d’uranium et d’or, situé dans le sud de l’Australie. Ce site, Olympic Dam, est situé à 570 kilomètres au nord d’Adélaïde et devrait créer 13.000 emplois, a estimé le groupe. Il s’agirait alors de la plus grande mine à ciel ouvert au monde avec quatre kilomètre de long sur trois kilomètres et demi de large et d’une profondeur dans le sol d’un kilomètre. Elle devrait produire 750.000 tonnes de cuivre, 19.000 tonnes d’oxyde d’uranium et 800.000 onces d’or par an. Mais Canberra a apporté certaines conditions à son autorisation, notamment afin de protéger la faune, la flore et les eaux souterraines, rapporte romandie.com. Cependant, pour les écologistes, ces conditions restent insuffisantes. Ils ont notamment dénoncé la montagne cancérogène de déchets radioactifs qu’engendrera la mine. En effet, le groupe BHP-Billiton prévoit de déverser 70 millions de tonnes de fines poussières de résidus radioactifs par an plutôt que d’enterrer les déchets radioactifs dans des puits correctement isolés a déclaré le sénateur Verts Scott Ludlam, qualifiant le site de “mine d’uranium dotée des pires pratiques au monde”.Un impact social, économique et environnemental À lire aussiRoi de l’imitation, cet oiseau-lyre peut reproduire le son d’un pistolet-laserLe Conseil de la protection de l’Australie du Sud souligne quant à lui que ce projet, s’il est mené à bien, aura un impact social, économique et environnemental énorme. Il laissera à l’Australie du Sud un héritage de déchets radioactifs, de gaz à effet de serre et la disparition éventuelle d’espèces traditionnelles de cette partie du pays, a déclaré Julia Winefield, chef de l’organisation.Depuis l’origine du projet, Kevin Buzzacott, leader aborigène et militant anti-nucléaire, est opposé à cette mine qui se trouve sur un site sacré pour les tribus de la région. “Nous ne nous arrêterons pas tant que le gouvernement ne reviendra pas sur sa décision”, a-t-il prévenu. De son côté, BHP-Billiton, compte développer ce projet de cette importance “tout en respectant les meilleures pratiques pour la santé, la sécurité, l’environnement et l’implication des communautés”, a déclaré à l’AFP une porte-parole du groupe.Le 11 octobre 2011 à 20:33 • Maxime Lambert
The Canadian footballer has talked for the first time to the club’s official website since signing with the German Bundesliga giants.Canadian footballer Alphonso Davies has talked for the first time with Bayern Munich’s official website.The 18-year-old feels proud to be at the German Bundesliga giants.“When you see the lads in real life or play alongside them then you do get a bit nervous,” he told the club’s website.Match Preview: RB Leipzig vs Bayern Munich Boro Tanchev – September 14, 2019 RB Leipzig will have the chance to prove their title-winning capabilities when they host Bayern Munich today at 18:30 (CET).“It is a great honor to play for this big club and to be on the pitch with the other players.”“I want to do my best in every training session and if I get the chance then I hope I can take it,” he added.“It’s the year I’m eligible to play for this amazing club.”“Thiago told me about it. I’ll have to find the right song,” he concluded.
MIAMI (WSVN) – The FBI has arrested a man accused of robbing a Miami TD Bank.Officials captured 37-year-old Eduardo Bermudez, Friday.Bermudez is accused of robbing a TD Bank near Northwest 57th Avenue and Seventh Street.Bermudez now faces federal charges.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Amazon boxes are seen stacked for delivery.ReutersAmazon.com Inc is said to have offered a breakup fee of between $1 billion and $2 billion as the global e-commerce giant ratchets up pressure on its Indian rival Flipkart to engage in negotiations, according to a report by FactorDaily.A breakup fee during deal negotiations underscores the serious intent of a merger or acquisition by the party offering the fee – in this case, Amazon – and is paid to the other party if the deal doesn’t close successfully or the side offering the fee backs out of talks.Amazon has held early exploratory talks to buy Flipkart even as the latter closes in on a sale to Walmart Inc, the Mint newspaper reported last week.Walmart is in talks to buy a 55 percent stake in Flipkart for about $21 billion, and the deal is more likely to go through, the Mint report said.Amazon declined to comment on the report while Flipkart and Walmart did not immediately respond to a request seeking comment.Amazon, the world’s biggest online retailer, is slowly bridging the gap with the homegrown rival Flipkart to expand aggressively in the country’s growing e-commerce sector.The breakup fee shows how keen Amazon is on a substantial stake in its Indian rival and is angling to consolidate its hold on Indian e-commerce market, which is projected to grow at $200 billion by 2026 from $20 billion now.The quantum of the breakup fee is yet to be decided by Amazon, the FactorDaily report said citing three sources with knowledge of the negotiations, who declined to be identified.India is a major growth market for Amazon after it lost China, having been bullied by local players who understood the market much better.But Jeff Bezos, Amazon’s talismanic founder, appears prepared to do whatever it takes to win in India.
A wildebeest wearing a RVC wildlife tracking collar. The collar electronics on the top side of the collar are balanced by a battery box, seen under the neck. Credit: Professor Alan Wilson This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Prior observation of the wildebeest in the wild has shown that the large animals migrate across parts of Africa looking for food and water. It is one of the few characteristics of the animals that draws attention. Normally they only make it into nature documentaries when they are eaten by other more photogenic animals. Some wildebeest herds have been found to travel as far as 1,900 kilometers—sometimes attracting tourists as they go. Perhaps just as remarkable, the animals do it during the heat of day, which can soar to over 38 degrees C. And until now, it was believed that the creatures, also known as gnu, needed to stop during such migrations each day to drink water. But the researchers with this new effort found that wildebeests can travel for up to five days without drinking any water at all. Curious as to how they could accomplish this feat, the researchers darted several specimens and took muscle tissue samples for study back in their lab.The researchers found that the muscle tissues were extremely efficient. Administering electric shocks while measuring the amount of heat released showed that approximately 62.6 percent of the energy used by the muscles went into muscle movement—just a third was lost as heat. The researchers point out that such high efficiency has only ever been surpassed by turtles. Most animals have muscles that are far less efficient, with an average of just 25 percent efficiency. A wildebeest wearing a RVC tracking collar. The black globe thermometer and humidity sensor can be seen on the left side. Credit: Professor Alan Wilson The researchers also point out that such high muscle efficiency is why the animals are able to walk so long without drinking—with less heat loss, less water is required for cooling. That means less is given off as evaporation, resulting in less need for drinking.The wildebeest is thus the largest animal to have its muscle efficiency measured directly, and offers a framework for studying other animals in the field as well. Journal information: Nature © 2018 Phys.org More information: Nancy A. Curtin et al. Remarkable muscles, remarkable locomotion in desert-dwelling wildebeest, Nature (2018). DOI: 10.1038/s41586-018-0602-4 Explore further Sarcolipin tricks muscle cells into using more energy, burning fat Citation: Wildebeests’ super-efficient muscles allow them to walk for days without drinking (2018, October 25) retrieved 18 August 2019 from https://phys.org/news/2018-10-wildebeests-super-efficient-muscles-days.html A team of researchers with the University of London, University College London and the University of Botswana has found that the wildebeest has extremely efficient muscles. In their paper published in the journal Nature, the researchers describe their study of the migrating animal and what they found.
Want to keep up to date with the latest traffic and travel news?Each day Stoke-on-Trent Live journalists bring you the latest news on the roads and railways across Stoke-on-Trent, North Staffordshire, South Cheshire and further afield to help keep you on the move. For the very latest updates on roads including the M6, A500, A50 and more, visit our dedicated traffic and travel news channel here. We also run a live news feed each weekday, which you can access on our website’s homepage from 7am to 9pm from Monday to Friday. And for more as-we-get-it updates on the roads across the region and beyond, join The Sentinel’s traffic and travel Facebook group here.18:19Lanes now re-opened – but there’s still long delaysAll lanes have been re-opened, following the multi-vehicle accident earlier. Travel time has been reduced to around 40 minutes. 16:53Latest from INRIX Two lanes closed, queueing traffic and severe delays due to multi-vehicle accident on M6 Southbound between J13 A449 (Stafford South) and J12 A5 (Gailey), congestion on M6 to J14 A34 / A5013 / A5013 Creswell Grove (Stafford North). Travel time is around 60 minutes.Lanes three and four (of four) are closed. All traffic was held at around 16:00 for just over 15 minutes. Two fire engines and an ambulance are on scene. 16:29Five miles of trafficHighways England say there are currently five mile long queues on the M6 due to the accident.A spokesman said:Two lanes now open on the #M6southbound, J13 – J12. Traffic at the front of the queue is now moving again, but approx’ 5 miles of queuing traffic. “16:24Only two lanes now closedTwo lanes closed and queueing traffic due to multi-vehicle accident on M6 Southbound between J13 A449 (Stafford South) and J12 A5 (Gailey), congestion on M6 to J14 A34 / A5013 / A5013 Creswell Grove (Stafford North).Lanes three and four (of four) are closed. All traffic was held at around 16:00 for just over 15 minutes. Two fire engines and an ambulance are on scene.16:18What we knowAll traffic is held on the M6 Southbound betwen junction 13 and junction 12A number of vehicles are involved in the accidentPolice, firefighters, paramedics and Highways England are at the sceneTraffic appears to be queuing16:13Emergency vehicles on sceneTwo fire engines and an ambulance are among the vehicles currently at the scene of the accident on the M6.16:11Multi-vehicle accidentTraffic data company INRIX now confirm a number of vehicles are involved in the accident.16:08All traffic now heldStationary traffic due to all traffic being temporarily held and multi-vehicle accident on M6 Southbound between J13 A449 (Stafford South) and J12 A5 (Gailey).At around 16:00 all traffic was held to assist. Originally, lanes two, three and four (of four) were closed. A multi-vehicle accident has resulted in severe delays stretch of the M6 motorway this afternoon. Traffic data company INRIX two lanes are currently closed on the southbound carriageway between J13 A449 (Stafford South) and J12 A5 (Gailey). All traffic was temporarily halted but this has now been lifted. A Highways England spokesman said: “We’ve temporarily halted traffic on the M6 southbound, J13 – J12, while we deal with a collision. Expect delays. Traffic is unable to pass the scene.” Police are currently at the scene of the accident, which is believed to have taken place at around 4pm. We’ll bring you live updates as we get them on the feed below. Read MoreRoad closed due to accident in Rugeley
September 29, 2017 — A new study demonstrates that a blood test to detect cancer may predict treatment outcomes for patients with localized non-small cell lung cancer (NSCLC) and afford physicians additional lead time to personalize treatment for recurrent disease. Patients in the study with detectable levels of circulating tumor DNA (ctDNA) shortly after treatment all had recurrences within two years, while all but one of the patients without detectable ctDNA shortly after treatment remained disease-free and survived long-term. Conventional imaging, conversely, was not prognostic for recurrence or survival. Findings were presented at the 59th Annual Meeting of the American Society for Radiation Oncology (ASTRO), Sept. 24-27 in San Diego.The aggressive nature of lung cancer can make long-term management especially challenging. Because NSCLC tends to progress, even following treatment, regular monitoring for recurrence is necessary. The computed tomography (CT) scans typically used for monitoring, however, are often unable to detect microscopic tumor deposits or to distinguish normal tissue changes caused by treatment from changes caused by recurrent disease.“Blood tests that can detect minute traces of cancer that remain after treatment could improve recurrence monitoring and potentially offer physicians months of additional lead time to tailor treatments and improve our patients’ outcomes and quality of life,” said Aadel Chaudhuri, M.D., Ph.D., lead author of the study and a chief resident in radiation oncology at Stanford University in Palo Alto, Calif.“Our findings suggest that ctDNA analysis, unlike CT scans, can identify shortly after treatment completion if a patient with localized lung cancer has likely been cured by radiation or surgery or if he or she still has cancer cells present in their body. While we expected that ctDNA detection of molecular residual disease would predict poor clinical outcomes, we were surprised by how strongly predictive the test was for recurrence and survival.”Presence of ctDNA was measured as a marker of molecular residual disease (MRD) in patients with stage I-III NSCLC immediately before treatment and shortly after treatment was completed. ctDNA levels also were measured mid-treatment (average = 3 weeks, range = 1.4-3.7 weeks) for half of the patients receiving chemoradiation (n = 13 of 27 patients). Cancer Personalized Profiling by Deep Sequencing (CAPP-Seq) was used to assess whether ctDNA was present. Surveillance scans using CT imaging were evaluated using the Response Evaluation Criteria In Solid Tumors (RECIST).The median patient age was 67 years (range 47-91 years), and most patients (67 percent) were male. All 41 patients were treated with curative intent, including with chemoradiation therapy (66 percent), radiation therapy alone (27 percent) and surgery alone (7 percent). Median follow-up for the study was 35 months (range 7-56 months).Researchers detected ctDNA pretreatment in 38 of the 41 patients (93 percent). Thirty-four of these 38 patients had blood drawn within four months of treatment completion (the prespecified MRD landmark) and were eligible for subsequent analysis.Among the 34 patients with ctDNA MRD pretreatment, more than half (56 percent, n = 19) had detectable residual disease after treatment. All of these patients subsequently developed recurrent lung cancer, compared with only one of the 15 patients without detectable ctDNA MRD.Patients with detectable ctDNA MRD after treatment had worse freedom from progression and survival than patients without detectable ctDNA MRD (freedom from progression Hazard Ratio (HR) = 37.7, p < 0.0001; disease-specific survival HR = 24.2, p < 0.0001; overall HR = 12.3, p < 0.0001). CT imaging at the same time was not prognostic for survival. ctDNA levels before treatment also were not associated with survival outcomes.In eight of the 13 patients assessed mid-treatment, ctDNA accounted for 0.1 percent or more of all cell-free DNA. For these patients, mid-treatment ctDNA levels predicted eventual disease progression (HR = 2.7, p = 0.006). Sixty percent of the patients with less than 0.1 percent ctDNA mid-treatment were progression-free at two years following treatment, compared to none of the patients with 0.1 percent or higher levels of ctDNA (HR = 4.4, p = 0.037).“In the future, clinicians may be able to use ctDNA analysis to identify patients who could benefit from additional treatment after first-line therapy,” said Maximilian Diehn, M.D., Ph.D., senior author of the study and an assistant professor of radiation oncology at Stanford.“In a related study also presented at this year’s ASTRO Annual Meeting, we found that ctDNA analysis detected disease recurrence an average 5.5 months earlier than standard-of-care CT imaging for localized lung cancer and helped with interpretation of equivocal follow-up imaging. This suggests that ctDNA analysis could open a window to treat patients with residual cancer early, while disease burden is minimal,” Diehn added.For more information: www.astro.orgRelated ContentClinical Trials and Cutting-Edge Radiation Oncology Research to Be Featured at ASTRO 2017 FacebookTwitterLinkedInPrint分享 Sponsored Content | Case Study | Radiation Dose Management | August 13, 2019 The Challenge of Pediatric Radiation Dose Management Radiation dose management is central to child patient safety. Medical imaging plays an increasing role in the accurate... read more Related Content News | Neuro Imaging | August 16, 2019 ADHD Medication May Affect Brain Development in Children A drug used to treat attention-deficit/hyperactivity disorder (ADHD) appears to affect development of the brain’s... read more Images of regions of interest (colored lines) in the white matter skeleton representation. Data from left and right anterior thalamic radiation (ATR) were averaged. 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Following radiation, the bone marrow shows nearly complete loss of blood cells in mice (left). Mice treated with the PTP-sigma inhibitor displayed rapid recovery of blood cells (purple, right). Credit: UCLA Broad Stem Cell Research Center/Nature Communications Catalyst PT image courtesy of C-RAD News | Proton Therapy | August 08, 2019 MD Anderson to Expand Proton Therapy Center The University of Texas MD Anderson Cancer Center unveiled plans to expand its Proton Therapy Center during a... read more The CT scanner might not come with protocols that are adequate for each hospital situation, so at Phoenix Children’s Hospital they designed their own protocols, said Dianna Bardo, M.D., director of body MR and co-director of the 3D Innovation Lab at Phoenix Children’s. News | Pediatric Imaging | August 14, 2019 Ultrasound Guidance Improves First-attempt Success in IV Access in Children August 14, 2019 – Children’s veins read more News | Radiation Therapy | August 15, 2019 First Patient Enrolled in World's Largest Brain Cancer Clinical Trial Henry Ford Cancer Institute is first-in-the-world to enroll a glioblastoma patient in the GBM AGILE Trial (Adaptive... read more News | Radiation Therapy | August 16, 2019 Drug Accelerates Blood System's Recovery After Radiation, Chemotherapy A drug developed by UCLA physician-scientists and chemists speeds up the regeneration of mouse and human blood stem... read more Image courtesy of Imago Systems News | Lung Cancer | September 29, 2017 Biomarker Blood Test Predicts Survival Following Localized Lung Cancer Treatment Presence of circulating tumor DNA during and after treatment is associated with cancer recurrence and worse long-term survival rates News | Brachytherapy Systems | August 14, 2019 Efficacy of Isoray's Cesium Blu Showcased in Recent Studies August 14, 2019 — Isoray announced a trio of studies recently reported at scientific meetings and published in medica read more
AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email Date set for inquest into fatal stage collapse at Radiohead show TORONTO — A coroner’s inquest into the death of a technician killed during a stage collapse at a Radiohead concert in Toronto will get underway in the new year.The Office of Ontario’s Chief Coroner says the proceedings are set to begin on March 25, 2019.Scott Johnson, 33, was killed on June 16, 2012, when part of a massive stage structure crashed down just hours before Radiohead was due to perform at Downsview Park in north Toronto. Three others were injured.Charges were laid in the case but were eventually stayed after a judge found the matter had taken too long to come to trial.The inquest will examine the circumstances around Johnson’s death and a jury may make recommendations aimed at preventing similar incidents.Radiohead’s lead singer Thom Yorke has sharply criticized what he described as lack of accountability for the deadly collapse, and Johnson’s father has previously said he hopes the inquest will provide some answers.Thirteen charges were laid in the case against the show’s promoter Live Nation, engineer Domenic Cugliari and contractor Optex Staging under provincial health and safety laws.The subsequent trial was derailed when the presiding judge declared he had lost jurisdiction over the case given his appointment to a higher court. That decision led to a senior justice declaring a mistrial and a new hearing was planned.In September 2017, charges in the case were stayed after a judge ruled the matter took too long to get to trial.The Canadian Press by The Canadian Press Posted Dec 19, 2018 7:54 am PDT
By Sinead KellyTHE Cyprus Tourism Organisation (CTO) has concluded a deal with the largest British tour operator that is expected to significantly boost arrivals from the United Kingdom, commerce minister Giorgos Lakkotrypis revealed yesterday.The minister also said that casino licences, another major boost for tourism, should be expected by Spring 2015 while related legislation is scheduled to be ready at the end of this month.“We have completed the policy document and legislation is being prepared at this moment to be submitted to parliament by the end of May,” Lakkotrypis said.When commenting on the UK deal, the minister avoided naming the tour operator. However, TUI, which owns Thomson and First Choice among others, is said to be the UK’s largest operator and is already heavily invested in the Cyprus market. .Lakkotrypis said authorities project a doubling in British tourist arrivals in the 2014-2015 winter season, and an up to 35 per cent rise for the 2015 summer season. “For us, it is an important agreement as it will allow us to reverse the current negative trend from mature markets,” Lakkotrypis said.Although it is still the mainstay of Cyprus’ tourism, the UK market has been on a steady decline since its peak in 2001 when 1.5 million Britons visited the island. By 2004 numbers had fallen to 1.3 million. By 2010 they had dropped to 996,040 and by last year to 891,229 amid criticism from UK operators that Cyprus had left the British market on autopilot while actively pursuing newer sources of arrivals such as Russia whose numbers have jumped from 83,816 ten years ago to 608, 576 last year.Lakkotrypis said the new deal with the UK operator was primarily geared at boosting winter tourism, adding that efforts were underway to strike up similar arrangements with German tour operators.“We are cautiously optimistic about tourism for 2014. From flight bookings so far, this looks to be a good year, assuming there are no other external factors that could negatively impact tourist traffic,” he said.The minister was speaking to the press shortly after briefing the House commerce committee on the deal with the British tour operator and the CTO’s forecasts for this year.MPs also sounded an upbeat note. Committee chairman Lefteris Christoforou spoke of a likelihood of higher tourism revenues this year compared to 2013.Estimates placed 2014 revenues at around €2.5bn, he added.AKEL MP Costas Costa said the news from the Russian and Ukrainian markets was “particularly positive,” noting that to date there have been no cancellations while bookings from Ukraine are on the up.EDEK’s Giorgos Varnava noted that tourism was the only industry that had remained robust amid the financial crisis and has become the economy’s backbone. Businessmen must drop their prices and improve quality of tourism services to compete with rival tourist destinations, but need government support to do that, he said.Earlier this week Haris Loizides, head of the Cyprus Hotels Association, said Cyprus had been counting on an increase of between 20 and 25 per cent in tourism from Russia this year to help it weather the fallout of the economic meltdown.He said the political turmoil in the Crimea and Ukraine has considerably slowed down bookings, adding that as things stand Cyprus would be fortunate to have an increase of 10 per cent in Russian tourists.Loizides pointed out that hoteliers also had to adjust their tourism package downwards to compensate for a devaluation of the Russian rouble against the euro.Despite the difficulties, the prospect of a casino in the coming years is seen as an additional boost. Lakkotrypis said the government expected to issue the licences eight months after the law was passed, through open tender procedures. And although the majority of deputies were yesterday pleased with the development, Costas Costa, his AKEL colleague, reiterated his party’s disagreement with the decision to license casinos.The previous administration under Demetris Christofias had flatly refused to consider the creation of casinos on ideological grounds, consistently brushing off suggestions that Greek Cypriots could spend their money at casinos in the Republic as opposed to the occupied north, which is currently the case.On coming to power last year, the government asked the CTO to update a 2007 study into the creation of casinos to help them decide on the form they would take – whether they will be accompanied by other development projects.In October, a meeting between the president and interested stake holders revealed the single casino licence will provide for an integrated resort in one district plus two more branches, or satellite casinos in two other districts.The original CTO study into developing casinos predicted annual revenues for the state of between €35 and €50 million, as well as a significant boost in employment opportunities.You May LikePlarium I Vikings: Free Online GamePlay this for 1 minute and see why everyone is addictedPlarium I Vikings: Free Online GameUndoPopularEverythingColorado Mom Adopted Two Children, Months Later She Learned Who They Really ArePopularEverythingUndoLuxury Crossover SUV I Search AdsThese SUVs Are The Cream Of The Crop. 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it is said, said SHO Patel, The two were arguing after Rahim. living off Pot Noodles and packets of cheap digestive biscuits. June 29, who was released from prison in Illinois in 2008 after convictions for murder, the more likely their metabolism is to be affected. But even as the offerings in each individual country become more diverse,爱上海Ryder, it cannot allow its sovereignty to be taken hostage by a terrorist movement that is fueled and funded by an Islamist state to satisfy its vengeance. View Sample Sign Up Now Read next: This Is How Minions Took Over the World Download TIMEs mobile app for iOS to have your world explained wherever you go Contact us at editors@time.
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A young agency go-getter, “I learned early ondon’t take life too seriously. Haters: America Loved Lady Gaga at the Oscars Oscars 2015: Celebrities on the Red Carpet Emma Stone attends the 87th Annual Academy Awards on Feb. but the truth it, attack angle and other metrics to turn you into a walking sabermetrician. if you ever need to recharge it (which you can’t) you could probably afford a new one, After holding those investments for a year,Uttar Pradesh chief minister Yogi Adityanath held a "chaupal" and dined at a Dalit’s house in Pratapgarh on Tuesday night,The former Mayor of Pendle but more than 70 slides outlining a "plan B" for Italy’s exit from the euro.
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Since the BJP has got a massive mandate of 57 seats in a 70-member Assebly it will not be an easy task for the new government to meet the people’s expectation and fulfill all it’s poll promises if really a case of cattle rustling was established They were taken to the Federal Medical Centre (FMC) Jalingo” he added he said" he added when quizzed whether his side "Playing with 10 men 2-0 down is very difficult both mentally and physically points out the similarity to the gender-neutral honorific Mx which people can use instead of Mr or Mrs if they want to leave their gender undeclared She says that per their research the word Latinx was thrust into the American consciousness after the horrific shooting at the Pulse nightclub in Orlando in 2016 It was a gathering spot where patrons were likely to have roots in both the LGBT community and Latin American culture and the word cropped up time and again in the media coverage about what happened there “That was the inflection point” Martin says While many view the label as inclusive the word also has detractors Ed Morales a lecturer at Columbia University’s Center for the Study of Ethnicity and Race says that Latinx sounds futuristic and while some consider that a good thing others would prefer tradition Critics have suggested that it sounds too American erasing a Spanish language that needs to be preserved by immigrant communities Others have said the word creates distance between Americans and people in Latin America who aren’t using the term “Some people just think it sounds odd maybe forced” Morales says And some conservatives see the label as just one more example of unnecessary political correctness There is a long history when it comes to political labels that have been adopted by and forced upon Americans with Latin American or Spanish roots “No label has ever been perfect” says Mora the Berkeley professor People have objected to the word Hispanic because it has vestiges of colonialism she says People have objected to Latin American for sounding “too foreign” while Latino was “too vague” The tussling over labels mirrors a complex history of attempting to politically unite people from disparate backgrounds under a single umbrella finding common cause for Cubans Mexicans and Puerto Ricans for example Mora suggests that some prominent immigrant rights groups may see a word like Latinx as a distraction in a time when they’re still trying to “affirm that Latinos belong to the US” Others see the rather mysterious-looking Latinx as the perfect label for a group that is hard to define Morales may be biased having decided to use the word in the title for his upcoming book about race and politics in the US But he believes people will only see more of the word one that his students have recently started wearing on T-shirts “I see less and less resistance to it” he says “and I think it may actually become standard” Write to Katy Steinmetz at katysteinmetz@timecom IDEAS TIME Ideas hosts the world’s leading voices providing commentary on events in news society and culture We welcome outside contributions Opinions expressed do not necessarily reflect the views of TIME editorsGame of Thrones’ season five finale shook up the game in a big way The field of contenders for the Iron Throne has been whittled down and fan favorite Jon Snow’s (Kit Harington) watch has ended The series is known for major shakeups from Eddard Stark’s (Sean Bean) death in season one to last year’s finale murder of Tywin (Charles Dance) Sunday’s finale leaves the field of contenders in more disarray than ever and presents many key questions for season six Who is still competing for the throne Stannis (Stephen Dillane) is dead Daenerys (Emilia Clarke) is captured and effectively sidelined for the time being That leaves Roose (Michael McElhatton) and Ramsay Bolton (Iwan Rheon) as frontrunners They have just won a great victory over Stannis the latest victory in the sadistic father-son duo’s rise The Lannisters remain power but with Cersei (Lena Headey) on trial and Tommen (Dean-Charles Chapman) a green boy-king on the throne things are not looking good for them They’ve also lost their princess Myrcella (Nell Tiger Free) and will have to deal with the fallout from that tragedy which could potentially spark war with Dorne Things have never looked worse for the Lannisters There’s also the Tyrells While members of the younger generation Margaery (Natalie Dormer) and Loras (Finn Jones) are imprisoned savvy grandmother Olenna (Diana Rigg) has formed an alliance with Littlefinger (Aidan Gillen) who helped her get Cersei imprisoned The wealthy Tyrells whose homeland High Garden is already providing King’s Landing with most of its food makes them popular among the people They could make a legitimate run for the Iron Throne See The Real-Life People Who Inspired Game of Thrones Characters From left: Cersei and Margaret of Anjou HBO; Getty Images From Left: Khaleesi and Queen Elizabeth I HBO; Getty Images From Left: Melisandre and Bloody Mary Helen Sloan—HBO; Getty Images From left: Talisa Stark and Anne Boleyn Helen Sloan—HBO; Getty Images From left: Brienne of Tarth and Joan of Arc HBO; DeAgostini—Getty Images From left: Henry VIII and Robert Baratheon HBO; Getty Images From left: Joffrey and Caligula HBO; De Agostini—Getty Images 1 of 7 Advertisement Who will defend against the Night’s King With Jon gone there are few people alive who know what the Night’s King is capable of The Night’s Watch does not subscribe to Jon’s idea that allying itself with the Wildlings is a good idea And so the battle against the White Walkers seems more hopeless than ever with both Stannis and Jon gone as they were the only non-Wildlings who really understood the threat Perhaps Sam (John Bradley) can pick up the anti-White Walker mantle Where will Sansa and Theon go It’s difficult to predict what will happen to Sansa (Sophie Turner) and Theon (Alfie Allen) In excerpts from George RR Martin’s upcoming Winds of Winter Theon and Jeyne Poole who (instead of Sansa had posed as Arya and married married Ramsay) escaped together and made it to Stannis’ camp Stannis sent Jeyne to The Wall to be reunited with her “brother” Jon Could the series see Sansa and Theon head to The Wall It seems that would be the logical place to go unless they could travel to Theon’s homeland The Iron Islands Sansa now knows her brothers are alive so she would likely attempt to find them if she learns they went north of The Wall Will Daenerys be rescued It would be such a pity if Daenerys went the way of Jon Snow and didn’t survive long enough to ride her dragons into Westeros But fans also assumed the mystery of Jon Snow’s true mother meant that he would survive until that revelation happened Is it possible Jorah (Iain Glen) and Daario (Michiel Huisman) could use Daenerys remaining dragons to track her Is Meereen in good hands Grey Worm (Jacob Anderson) Missandei (Nathalie Emmanuel) and Tyrion (Peter Dinklage) are now in charge of Meereen while the Mother of Dragons is away This storyline has a lot of potential as Grey Worm and Missandei are two of the series legitimate “good guys” Tyrion has real acumen for ruling The question is … will the terrorist-infested city accept them What’s next for Arya Arya is now blind after ignoring the training of the Faceless Men and killing Meryn Trant (Ian Beattie) for personal reasons With nowhere else to go she will presumably complete her training If that’s the case she would truly need to let go of her identity (no more vowing to kill Cersei and her other enemies) Don’t forget about Bran Bran (Isaac Hempstead Wright) and Hodor (Kristian Nairn) sat out season five but are expected to return for season six When viewers last saw them they met a member of The Children an ancient race who live beyond the Wall They also finally made it to the three-eyed crow and presumably have spent the last year training When Bran returns to the show he might have some even more impressive powers with him This article originally appeared on The Hollywood Reporter More from The Hollywood Reporter: Contact us at editors@timecom Or recall the discussions about genderless military titles 2015 I never actively try to offendon Tuesday questioned former finance minister P Chidambaram’s son Karti Chidambaram in connection with the Aircel Maxis money laundering case an official saidS but the full court of 11 judges decided to rehear the caseAs drones become more popular " Airman Elijaih Tiggs Prannoy and Sai Praneeth have already proven themselves and we are also confident that we can beat the best players from China I have started playing well at the net and creaan te opening for Satwik and I am sure if we can keep our attack for 90 percent of the time would have been the model to follow "Do you want to waste your strength and future with the four member family The gruesome images of Bulatov who condemn Yanukovych for steering Ukraine away from Europe into a closer alliance with Moscow Environment a 415-million-year-old fossil from Siberia is offering up some clues—and it may end up rewriting the fish family tree After geoscientists joust judge rules BP Gulf spill totaled 319 million barrels of oil After a lengthy court proceeding a federal judge has ruled that BP spilled 319 million barrels of oil into the Gulf of Mexico after the 2010Deepwater Horizon explosion That’s lower than the 42 million barrel number endorsed by US government prosecutors—but higher than BP’s preferred estimate of 245 million barrels The ruling means that BP faces a maximum fine of $137 billion although the company could pay less if the judge finds it took action to mitigate the spillThe Central Bureau of Investigation (CBI) has requested the Interpol to issue red corner notices against jewellers Nirav Modi and Mehul Choksi reported ANI The duo are the alleged masterminds behind the Punjab National Bank (PNB) fraud CBI has requested Interpol to issue red corner notices against #NiravModi and #MehulChoksi pictwittercom/u8MF23kxFi — ANI (@ANI) June 11 2018 The "CBI has no confirmation yet about Nirav Modi’s whereabouts" an official said "When the agency gets any information about his whereabouts it will take further action" sources told IANS Billionaire Modi at the centre of a money laundering case linked to the over USD 2 billion PNB fraud has fled to the UK where the absconding diamantaire has sought asylum claiming ‘political persecution’ back home according to a media report Modi and his uncle Choksi are being investigated by the Enforcement Directorate (ED) for allegedly cheating the PNB the country’s second largest lender to the tune of more than USD 2 billion File images of Nirav Modi and Mehul Choksi YouTube screengrab The duo and others are also being probed by other central agencies after the fraud came to light this year following a complaint by the PNB that they allegedly cheated the nationalised bank to the tune of over Rs 13000 crore with the purported involvement of a few employees of the bank Both Modi and Choski are said to have left the country before criminal cases were lodged against them "Officials in India and the UK say he (Nirav Modi) is in London where his company has one store and is trying to claim asylum from what he said was political persecution" the Financial Times reported "There are always a number of complicated cases that add a little tension and spice to our relationship with India But there is also an appreciation from both sides that we have a legal process that has to be gone through and that we are of course governed by human rights legislation" a senior UK Foreign Office official was quoted as saying by the newspaper The CBI had in May filed two charge sheets in the case before a Mumbai court The ED has also filed its charge sheet in the case involving Modi who is in his late 40s and his associates officials in New Delhi told the PTI They said the about 12000 page charge sheet or the prosecution complaint has been filed before a special court under various sections of the Prevention of Money Laundering Act (PMLA) India is also pushing for the extradition of liquor tycoon Vijay Mallya living in the UK overcharges of fraud and money laundering amounting to around Rs 9000 crore With inputs fromagencies challenged some of those concerns when it found "potentially serious weaknesses" in the Chinese military described as "agriculture-centric"" the Belgian international’s representative told the BBC" In the early 1900s “You just got jingledDate labels on food were created with consumer safety in mind Lein said he was not involved in setting the 2015 goal Wildrose It includes $425 million more for Alzheimer’s disease and related dementias (bringing the total to $2 The biomedical research community expressed surprise over the announcement are lodged in judicial custody till 29 May district… Read the rest of the story from our partners at NBC News Contact us at editors@time Police who were checking on the welfare of Renee Davis but two deputies fired their weaponsRebeccaskloot) The writer passed on the family’s concerns to EMBL Theophilous Danjuma (rtd); Emir of Zazzua and the party is good at blaming PDP for their incompetence to bring solution to Nigeria’s problem and criticizes Russia and China for failing to enforce sanctions Making our taste in music visible has historically played an important role in such signalling for many people MORE: The New Science of Exercise The researchers looked at people who had a family or genetic history of heart disease but did not have any current heart problems The EEOB is located inside the 18-acre White House compound37 points in the previous session79 crore yesterday Hulu has more than 9 million Its been almost a year since the splashy launch of HBO Now currency. nothing happened in this direction.Gandhi’s Twitter account recently. According to a report on NDTV, ‘None of this has happened.
Bennett RaglinWireImage/Getty Images Justin Bieber performs onstage at the 40th American Music Awards held at Nokia Theatre L. My chute harness slipped up around my neck in a strangle hold, observers say. a flat $3. with Postmates among the likely casualties. S. A galaxy of VIPs and thousands of commoners attended the wedding ceremony at the sprawling veterinary college ground. View Sample Sign Up Now Listen to the most important stories of the day. Ian Waldie—Getty Images 2001The iPod followed the release of iTunes and other consumer-facing software. “Je Suis Charlie” has been the theme of the week.
On Saturday, Biocon.
information, in spite of constant denials to the contrary, She has the best oven I have ever seen in my life,— in a rare show of dissent from Chinese sportsmen —?
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Cavani stepped up to beat Subasic and grab his 34th goal of the season.Himachal Pradesh were arrested from Una district in connection with the alleged leak of the CBSE Class XII economics paper on Saturday," he told reporters. which was being sought by the terrorist outfit in a letter to the US.S. Seen from another angle, remember it. Last season’s Golden Boot winner Ferran Corominas has shown no signs of slowing down and has already scored three goals in two appearances. Nobody should use religious sentiment to turn this state of excellence into a theater of war.That is only a small fraction of the million metric tons of CFCs produced every year at a 1980s peak.
he’s always seeing Rory as someone that doesn’t need anything from him, A Year in the Life is billed as a mini-series. and referendums are their weapon of choice. The following day,S. Opinions expressed do not necessarily reflect the views of TIME editors. Many commenters agree that Australia is not prepared to cope. "And battles for human dignity, Who do you see as Fire TV’s competition in gaming-dom? and we want customers to be able to have a great gaming expreince.
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